| Title | [Reversal of acenocoumarol anticoagulation with activated factor VII in massive hemorrhage following rupture of a splenic artery pseudoaneurysm] |
| Author(s) | Varela CA, Gómez JM, Reina MA, López A, Galindo S, Arruga AM |
| Institution | Servicio de Anestesia, Hospital Universitario de Madrid-Montepríncipe, Madrid. carlosvarelac@yahoo.es |
| Source | Rev Esp Anestesiol Reanim 2009 Apr; 56(4):245-8. |
| Abstract | A 66-year-old man with a metallic valve and under treatment with acenocoumarol developed hypovolemic shock after rupture of a splenic artery pseudoaneurysm. We managed to reverse anticoagulation within 60 minutes by administering 20 mg of vitamin K and 4.8 mg of activated recombinant factor VII. No thromboembolic adverse events were observed. We discuss the pharmacologic effects of coumarin derivatives and their antagonists, as well as the use of activated factor VII in the reversal of anticoagulation by these drugs. |
| Language | spa |
| Pub Type(s) | English Abstract
Journal Article
|
| PubMed ID | 19537265 |
